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It works the same way mechanistically, activating the GLP-1 receptor to reduce appetite, slow gastric emptying and improve insulin sensitivity, but the small molecule structure means it can be taken orally with fewer absorption constraints. In trials, orforglipron lowered blood sugar and produced meaningful weight loss in people with obesity and in those with type 2 diabetes, says LaValle

Now, a new study published in Led by researchers from the University of Pennsylvania, the study examined more than 400,000 Reddit posts from nearly 70,000 users discussing GLP-1 receptor agonists, including semaglutide and tirzepatide

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