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In accordance with this, it has been estimated that the steady-state concentration of superoxide in the mitochondrial matrix is 5- to 10- fold higher than in the cytosol (Fernandez-Checa and Kaplowitz, 2005

Second, both the genetic association with the Slc1A1 gene and the findings from specific animal models suggest that primary perturbations in glutamate signaling within this circuit can lead to OCD, or at least to OCD-like behaviors

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Direct measurement of extracellular lactate in the human hippocampus during spontaneous seizures