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Bad kidney function can cause too much B12 to build up, leading to problems

For significant wounds, combined use under clinical direction makes sense

Similarly, as iron levels are tightly controlled within the host, conditions of low iron are a potent inducer of capsule formation [260]

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Future studies demonstrated that KEAP1 does not passively sequester NRF2 in the cytosol, but actively functions as a ubiquitin ligase, leading to ubiquitination and proteasomal degradation of NRF2 (Zhang and Hannink, 2003)