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10.1146/annurev-neuro-090919-022842 111 MaroteauxL.CampanelliJ

If the patient is suspected to be sensitive to cobalt or other components of cobalamin, an intradermal test dose is recommended.[12][15] Several laboratory tests should be performed prior to treatment with cyanocobalamin, including serum vitamin B12, folate, iron, hematocrit, and reticulocyte count

Leveraging advanced technologies such as high-throughput sequencing, single-cell sequencing, and proteomics can provide a more comprehensive understanding of the mechanisms of hypoxia across tissues and cells, underpinning precision medicine

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