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Originally the source for intrinsic factor was virtually unprocessed normal gastric juice obtained from healthy volunteers

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Accordingly, many lines of evidence indicate that Nrf2 overactivity is implicated in chemoresistance to different conventional drugs including cisplatin [78], 5-fluorouracil [79], doxorubicin [80], vincristine [81], etoposide [82] and mitoxantrone [83]