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This altered metabolic profile can persist for days to weeks, suggesting that gut dysbiosis may span the entire disease course and influence immune status in distant organs (181)

Immune cells use ROS to sustain their functions and need adequate levels of antioxidant defenses to avoid harmful effects caused by excessive ROS production, since accurate balance between ROS and intracellular antioxidants is essential for a normal function of the cell (Banjac et al., 2008

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