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The baseline assessment of GCGR was performed on a Friday and of the GLP1R on the following Monday

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Consequently, bisphosphoglycerate phosphatase activity is favored over the kinase activity and leads to the depletion of 2,3-diphosphoglycerate (2,3-DPG), which in turn negatively impacts oxygen binding and off-loading kinetics 13,14

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GHRP-2 is the step up when more GH output is needed