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2 Mechanisms of OS-induced nerve damage In the context of DN, OS contributes to oxidase activation, mitochondrial dysfunction, apoptosis, inflammation, and endoplasmic reticulum (ER) stress, which are critical in the pathogenesis of nerve injury (Figure 1)

Hydroxocobalamin or methylcobalamin are preferred alternatives in such cases

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Diet, nutrition and the ageing brain: Current evidence and new directions