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Many people taking GLP-1 medications report: Reduced thirst Decreased fluid intake Constipation Fatigue Headaches Recommended Water Intake A practical goal for most adults is: 80-120 ounces of water daily A more personalized recommendation is: Half your body weight in ounces of water per day Examples: 180 pounds = 90 ounces daily 220 pounds = 110 ounces daily Increase hydration if you: Exercise regularly Spend time outdoors Live in a dry climate Drink caffeine frequently Signs You Need More Water Headaches Fatigue Dark urine Dizziness Constipation Some patients struggling with hydration may benefit from IV Therapy to help replenish fluids and nutrients

Nature 469 , 148149

Results Trial population Of 62 screened individuals, 49 (29 males and 20 females) were randomized and were exposed to trial drug

It is pharmacokinetically puzzling as an oral therapy because, as a peptide, it faces the usual hurdles of gastric degradation and poor epithelial uptake

Discard if cloudiness, particles, or contamination appears