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Notably, these authors included in their analysis only randomized controlled trials with a duration 52 weeks considering that interventions shorter than that were unlikely to affect the fracture risk [13]

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However, this low rate of serious events creates a false sense that all discomfort should be dismissed as "the drug working." Persistent constipation, worsening stomach pain, or escalating symptoms often get normalized as inevitable rather than reported, blurring the line between expected adjustment and situations requiring medical attention

Supportive supplements and dietary adjustments can help manage many of these symptoms effectively

Peripheral arterial thrombosis may cause sudden limb pain, pallor, coldness, and absent pulses