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94 Moreover, SLC1A3 is mainly expressed in brain tissue, and its high expressions in some solid tumors, such as clear cell renal cell carcinoma, papillary renal cell carcinoma, hepatocellular carcinoma and gastric adenocarcinoma, may make SLC1A3 inhibitors a solution to ASNase resistance

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A significant finding is its effect in pathological scarring models, such as keloids, where it promoted apoptosis in resistant fibroblasts and reduced cell proliferation during the G0/G1 phase of the cell cycle