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Collectively, these studies highlight the potential role of endocrine and central (hypothalamic) dysfunction in the altered homeostatic metabolic status in AN, as described in animal models (Boghi et al., Figure 2 At the hypothalamic level, ghrelin has also been reported to act directly or indirectly on other nuclei linked to feeding control such as the VMH, PVN, and LHA (Lpez et al., 2008

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10.3390/ijms131113830 77 MatteraR.BenvenutoM.GigantiM

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