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2019;24(11):E2138.doi:10.3390/molecules24112138 Mereles D, Hunstein W.Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls thanpromises

Topiramates effect on weight reduction and long-term maintenance of body weight may be due to its effects on both appetite suppression and satiety enhancement, induced by a combination of pharmacologic effects including augmenting the activity of the neurotransmitter gamma-aminobutyrate, modulation of voltage-gated ion channels, inhibition of AMPA/kainite excitatory glutamate receptors, or inhibition of carbonic anhydrase

Weight management plays a pivotal role too, as shedding extra pounds can significantly reduce insulin resistance

What side effects might occur

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it