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This largely comes from bioavailability studies such as a randomized, controlled trial from 2018, which showed identical doses of ubiquinone and ubiquinol resulting in greater serum CoQ10 concentrations among the ubiquinol group.34 Thats certainly important, but it was a very small study (only ten participants), and it doesnt give us a sense of actual efficacy for any use case

Wang Z, Ohata Y, Watanabe Y, Yuan Y, Yoshii Y, Kondo Y

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PMID: 20803613

The criterion exists because in clinical experience the predictable failure mode for peptide therapy is prescribing the second-best peptide for a patient whose presentation pointed to a different first choice