The peptide itself is essentially a copper-delivery vehicle, without intact Cu coordination (color check: deep blue), the molecule loses most of its biological activity
Acknowledgements The authors acknowledge the support of NIH grants DK126715 (R.D.C.), F32HD095620 (P.S.), K99DK127065 (P.S.), R00 DK127065 (P.S.), Brain and Behaviour Research Foundation Young Investigator Award (P.S.), Foundation for Prader Willi Research (P.S.), Courage Therapeutics (R.D.C.) and The Klarman Family Foundation (R.D.C.)
41 GaoL
Interestingly, a study conducted by Meng et al 14 showed that TMAO could further activate CSNS and initiate arrhythmia via direct way through the left stellate ganglion and indirect mechanisms by the central nervous system
A special thanks to Hartmut Jaeschke and Anup Ramachandran from University of Kansas who have been generous in sharing several illustrations that I have significantly modified, but which saved weeks of time in preparation of this post