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Evidence: GLP-1 Medications and Cholesterol Semaglutide and Tirzepatide Earlier GLP-1s like semaglutide and dual agonists like tirzepatide already showed modest improvements in lipid profiles: LDL cholesterol reduction by 510% Triglyceride reduction by 1520% Mild HDL increase These effects were partly due to weight loss , but researchers suspected other mechanisms were at play

A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)

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FAQ Frequently Asked Questions About Bacteriostatic Water What is bacteriostatic water used for in research

It works with your GLP-1 therapy rather than around it