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excretion as metabolites only Apparent population mean clearance of 0.061 L/h The majority of the administered dose is recovered within 480 hours (approximately 20 days) following a single subcutaneous dose in human studies

Metabolic Effects of GLP-1RA Administration The administration of GLP-1RAs, like liraglutide, exenatide, semaglutide, and lixisenatide, has multiple metabolic effects, such as glucose-dependent insulin secretion, slower gastric emptying, increased natriuresis and diuresis, increased pancreatic -cell mass, regulation of lipid metabolism, and decreased fat deposition, and has attracted considerable interest in recent years for its role in improving glycemic control and aiding weight loss in T2DM patients [48]

A group receiving 0.5 dose of commercial IPV (containing 20 units of PV1 D-antigen) served as a positive control, while a group of mice administered PBS buffer served as the negative control

Trial participation depends on protocol criteria, site availability, screening, and sponsor processes