In humans, metabolically healthy obesity is associated with smaller adipocytes and a lower visceral-to-subcutaneous fat ratio, whereas expansion of visceral fat correlates with systemic insulin resistance and ectopic lipid deposition 46,47,48
2026 - evaluation framing) New and diffuse pigmentation with systemic symptoms like fatigue, weight changes, or skin darkening elsewhere on the body - This pattern raises the possibility of an endocrine condition such as Addison's disease
In this article, well break down the latest evidence, side effect profiles, and long-term considerations to help you make an informed decision on GLP-1 therapy
Additionally, patients experienced modest weight loss averaging 2 to 3 kg over 6 months, an unexpected but welcome effect that distinguished GLP-1 receptor agonists from many other diabetes medications that cause weight gain
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