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High affinity binding sites are located at the N-terminal domain and the first Kringle domain of the -chain

The multiple pharmacological treatment options will enhance clinicians ability to identify effective personalised regimens by trying a second medication or combining medications with synergistic or complimentary actions or even escalating treatment to bariatric surgery based on patient preference and underlying comorbidities [7]

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The inhibitory molecule SR12343 has been shown to cross the blood brain barrier positioning it as an interesting compound to test in the context of AD and other neurodegenerative/neurological conditions (90)