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Aside from this cytokine profile, intra-islet macrophages secrete NO and chemokines, and express chemokine receptors (notably CCR5, CXCR3 and CCR8) which further recruits and activates other pro-inflammatory immune cells (61, 62)

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Moreover, FosB expression was increased in anorexigenic proopiomelanocortin neurons within the hypothalamic arcuate nucleus, which reduce feeding and have been implicated in promoting sympathetic excitation

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