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Side Effects and Management Strategies Gastrointestinal effects represent the most common adverse reactions to Retatrutide, consistent with other incretin-based therapies

It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity

Efficacy and safety of semaglutide for weight loss in obesity without diabetes: a systematic review and meta-analysis

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It stimulates insulin secretion in a glucose-dependent manner, slows down digestion, reduces food intake, increases urine production, and affects the growth of beta cells in rodents