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The STEP program studied it for weight management (published in The New England Journal of Medicine , 2021), while SUSTAIN and SELECT addressed diabetes and cardiovascular outcomes

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Primary care-based investigation of the effect of sitagliptin on blood pressure in hypertensive patients with type 2 diabetes

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4 Zeisel SH, da Costa KA Choline: an essential nutrient for public health (Nutr Rev, 2009)Review establishing that choline deficiency causes hepatic fat accumulation and liver injury, and that repletion reverses deficiency-related steatosis