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For example, the LEADER trial showed this benefit for liraglutide, and the SUSTAIN-6 trial demonstrated similar outcomes for semaglutide in people with type 2 diabetes and high cardiovascular risk

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Its antimicrobial properties can lead to a chronic autoimmune cycle caused by erroneous attacks on self neurons, and its immunomodulatory properties affect microglia function, which ultimately leads to neuronal death [147]