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The endoplasmic reticulum (ER), the largest organelle in animal cells, is a complex network of membranes involved in protein processing, modification, and calcium homeostasis [4]

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In the current study, depriving RPE cells of the essential GSH precursor Cys 2 by culturing cells in Cys 2 -free culture medium or blocking de novo synthesis of GSH by using GCL inhibitor BSO or blocking Cys 2 uptake by pharmaceutical inhibition of system x c caused cell death

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