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[15] Methionine donates methyl groups for the synthesis of S-adenosyl-methionine, which in turn drives phosphatidylcholine production and very-low-density lipoprotein assembly, facilitating export of triglycerides from hepatocytes and mitigating diet-induced steatosis

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There arent universal guidelines on milk thistle dosage, but clinical studies have found that 2,100 mg of milk thistle per day is well tolerated