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As a result, current clinical guidelines for T2DM, kidney disease, and cardiovascular care strongly recommend the use of GLP-1RAs and SGLT2is in patients with T2DM who have, or are at high risk for, atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), or chronic kidney disease (CKD)

Much of the reported 40% lean mass loss with GLP-1 use is coming from the liver. The actual skeletal muscle impact is far less dramatic than the headlines suggest

Glucagon serves as a counterbalance to insulin

More research is needed to understand why GLP-1s appear to reduce food noise, but it could be due to the reduced appetite and how the medications signal to the brain, which could help you focus less on hunger and eating throughout the day