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But what exactly are they

Over weeks of dosing, those small errors compound

What Clients Are Telling Me about their experience with GLP-1s Client responses to GLP-1s vary widely: Some experience little to no appetite or weight changepossibly requiring dose adjustments

Ueda P, Sderling J, Wintzell V, Svanstrm H, Pazzagli L, Eliasson B, Melbye M, Hviid A, Pasternak B

Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc