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In higher eukaryotes, this activation also requires the action of CDK11, which phosphorylates SF3B1, a core splicing factor and component of the U2 snRNP

Epigenetic regulation of CSCs Epigenetic mechanismsincluding DNA methylation, histone modification, and chromatin remodelingplay pivotal roles in regulating CSC properties such as self-renewal, plasticity, differentiation, and therapeutic resistance

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Ideally, they should be kept in a refrigerator at temperatures between 2C to 8C

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