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doi: 10.1007/s11154-016-9370-3 [DOI] [PubMed] [Google Scholar] 201

Cotadutide (MEDI0382) is the most extensively developed dual GLP-1/glucagon receptor agonist, showing significant improvements in glucose control, BW (likely mediated by reduced energy intake rather than increased energy expenditure), hepatic fat, and albuminuria in a small RCT on patients with T2D and overweight or obesity 45,46

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FIGURE 11 In conclusion, PCs demonstrate significant neuroprotective effects through their antioxidant, anti-inflammatory properties, and maintenance of blood-brain barrier function