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doi: 10.1186/s12916-025-03881-x 106 PowellC

The copper-binding tripeptide has been shown to stimulate collagen synthesis in fibroblast cell cultures, promote decorin and glycosaminoglycan production, and modulate expression of metalloproteinases (MMPs) involved in extracellular matrix remodeling in vitro

Conversely, SIRT3 overexpression has the opposite effects, 105 suggesting that SIRT3 inhibits AKT-dependent mitochondrial metabolism and EMT, thereby promoting ferroptosis