One study reported that GLP-1 is negatively correlated with body mass index (BMI) and that it appears to increase dentate gyrus neurogenesis based on immunostaining images (Coplan et al., 2014)
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Furthermore, a meta-analysis suggested a possible association between GLP-1RAs therapy and an increased relative risk of thyroid cancer in clinical trials, with liraglutide, exenatide, and dulaglutide potentially elevating cancer risk in patients with type 2 diabetes [9]
In addition, increasing TFAM levels enhanced mitochondrial DNA transcription and replication, aiding in the recovery of mitochondrial function, while boosting GPX4 levels directly reduced LPO buildup, thereby preventing ferroptosis
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