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IGF-1 LR3 is not appropriate for patients who are pregnant or breastfeeding, have active cancer or a cancer history (because IGF-1 stimulates cell growth broadly, including potentially malignant cells), have uncontrolled diabetes or diabetic retinopathy, or are under 21

Failure of Lifestyle Monotherapy Lifestyle modification (LSM) is foundational but often insufficient for long-term weight maintenance in Class II or III obesity: Timing: Patients with a history of weight cycling (yo-yo dieting) are unlikely to achieve sustained success through behavioral interventions alone

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doi: 10.1016/j.taap.2010.01.004