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Pooled Phase III analysis (n=816) Consistent VAT reductions across both trials with maintenance during continued therapy and regression toward baseline after stopping

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Bone histology Tibial bones and inflamed paws with tarsal joints were fixed in 4% formalin for 24 h and decalcified in Ethylenediaminetetraacetic acid (EDTA) (Sigma-Aldrich)

MC1R Binding and Eumelanin Signalling MT-1 exerts its primary pharmacological action by binding to the melanocortin 1 receptor (MC1R) on melanocytes in the skin

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