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3 Extended Administration Pharmacokinetics in DIO Mice Neelakantan et al., Biochemical Pharmacology (2024) This study reported a 28-day once-daily administration protocol of 5-Amino-1MQ in diet-induced obese mice, characterizing plasma pharmacokinetics, tissue distribution, and effects on body composition, fatty liver pathology, and circulating biomarkers

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These transgenerational effects operate primarily through epigenetic modifications, germline transmission of molecular alterations, and persistent fertility impairments that challenge traditional concepts of toxicological risk assessment (84)