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The impacts of synaptic dysfunction in MS and other IDDs has led our group to study particularly the effect of myelin proteins in synaptopathy

Efforts to standardize assays have improved this situation, but clinicians must still be aware of potential variability when interpreting results

Clin J Gastroenterol

Below are symptoms commonly attributed to b12 deficiency: Anemia Fatigue Weakness Constipation Loss of Appetite Weight loss Numbness or Tingling Depression Confusion Memory Impairment Burning Tongue/Mouth Dosages A 2015 paper published by the EFSA Panel on Dietetic Products considered 8 separate studies on Vitamin B12 ranging in dosages of 1.5-3.0 mcg/day