When it comes to the effect of GLP-1 analogues the reduction in postprandial glucose response, and insulinemia may actually contribute to weight loss, but also be the key drivers to the anti-diabetic effect and reduction in cardiovascular disease risks
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It works by simultaneously activating the glucose-dependent insulinotropic polypeptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1R), which results in increased insulin release, decreased glucagon secretion, reduced hunger, delayed gastric emptying, and significant weight loss
Xenical is a tool to aid weight loss, not a permanent cure for obesity