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This result was surprising since we initially hypothesized that OTA may be metabolically activated by CYPs because of the previously observed hepatotoxicity specifically in the cytochrome P450 positive pericentral lobular zone (Atroshi et al

GLP-1 medications like Ozempic (semaglutide GLP-1) are generally considered safe for long-term use when prescribed and monitored by a healthcare provider

And the main problem of megadosing that for anyone would be it would be imbalance with something else

Of note, only four of the articles specifically indicated that the initial 120 weeks of GLP-1 RA treatment was associated with an increase in retained gastric contents, with the highest increase within the first 12 weeks (Ushakumari and Sladen 2024