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As hepatocytes do not express the GLP-1R, the benefits of semaglutide may be secondary to weight loss or indirect reflecting local or systemic actions of semaglutide to improve hepatic metabolism and inflammation (Figure 1B)

Pregnancy and lactation are typically considered contraindications unless specifically approved by obstetric care

This means they cant control the amount of sugar in the blood

Audit Alert CMS and RAC auditors frequently target E66.9 (obesity, unspecified) when the medical record contains physician documentation of morbid obesity or BMI 40

Dosing starts at 2.5 mg once a week and increases to 5 mg once a week after a month, up to a maximum dose of 15 mg once weekly