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When sulforaphane was provided to male Wistar rats for 3 days prior to performing exhaustive exercise, sulforaphane served as an indirect antioxidant in skeletal muscle, as measured by decreased tissue total antioxidant capacity in the vastus lateralis muscle

Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

Complete immobilization produces weak, disorganized repair tissue while progressive loading promotes strong, aligned structures