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This celebrated result was followed in 1983 by the work of Graeme Bell and colleagues at the Chiron Corporation (California), who cloned hamster and human cDNAs encoding preproglucagon [34, 35]

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This is the most commonly referenced beginner structure

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Similar to previous peptide-bound:GLP-1R:G s complex structures, the highest resolution was observed within the G protein and receptor TMD, with lower resolution in the extracellular half of the receptors, including the ECD (Supplemental Figure 1), indicative of greater flexibility in these regions