tirzepatide dopamine attenuates mesolimbic cocaine-evoked levels and reduces cocaine taking, motivation and seeking behaviours in male rodents Mounjaro, Dopamine and the Brain:

In mitochondrial muscle disease, however, both muscle and blood showed decreased NAD + levels 15,30 suggesting that blood is a valid source of redox-metabolite analysis in the context of pathology

Serious adverse effects include pancreatitis, gallbladder disease, acute kidney injury (secondary to dehydration), and hypoglycaemia (when used with insulin or sulfonylureas)

doi:10.1097/HC9.0000000000000352 9Cusi K, Isaacs S, Barb D, et al

Mitochondrial calcium overload plays a causal role in oxidative stress in the failing heart

If you're on tirzepatide and also taking diabetes medications like metformin or insulin, the combined effect creates significant hypoglycemia risk