Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels
Because it works through a natural feedback loop, the body prevents overstimulation and keeps hormone levels balanced
She has authored more than 150 peer-reviewed publications and 15 invited articles, including reviews, editorials, commentaries, and perspectives, with over 70,000 citations, including numerous first-, senior-, and corresponding-author papers in top-tier and high-impact journals such as Nature (5), Nature Medicine (4), Cancer Cell (5), Cancer Discovery (4), Nature Biotechnology , Nature Genetics (2), The Lancet Oncology, Journal of Clinical Oncology, Gastroenterology, Gut (2) , Science Translational Medicine , and Nature Communications (10), as well as invited review articles in premier journals including Nature Reviews Molecular Cell Biology , Nature Reviews Clinical Oncology , Cancer Cell , Annual Review of Medicine , and Trends in Cancer
Diagnostic Uses Besides the therapeutic possibilities, there are also diagnostic opportunities
Last reviewed: June 19, 2026 Last updated: June 19, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations