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In reducing the risk of major adverse liver outcomes and HCC, large-scale observational studies and meta-analyses have demonstrated that GLP-1RA and SGLT2i exhibit comparable protective effects, with both showing significant superiority over traditional hypoglycemic agents such as DPP-4i and sulfonylureas

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doi: 10.1210/jc.2015-1176 53 Pacheco-PantojaELRanganathLRGallagherJAWilsonPJFraserWD

Mankin, H

This complex interplay within the Nrf2/HO-1 pathway remains under active investigation, as it represents a double-edged sword that can be either protective or harmful depending on the precise balance of iron and ROS levels within the cell (37)