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Early Discoveries, With More to Come So far, GLP-1s, first approved 20 years ago for type 2 diabetes and later obesity, have shown potential in treating a surprisingly wide range of conditions, such as heart disease, Parkinsons, Alzheimers, sleep apnea, and liver disease

Paranoia and Anxiety: Misuse heightens feelings of paranoia and anxiety due to overstimulation of the brains fight-or-flight response

Several plausible mechanisms may hypothetically explain why patients on GLP-1 therapy experience muscle cramps, even in the absence of a direct pharmacologic effect

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