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Diabetologia 66:17801795

Recent studies revealed that Wilms tumor gene on the X chromosome (WTX) and PALB2, a major BRCA2 binding partner known as FANCN, have been shown to interact with the DC domain of KEAP1, inhibit the ubiquitination of Nrf2 and promote NRF2-dependent transcription ( WTX and PALB2 are both considered as tumor suppressor genes since their mutations are often found in kidney tumor (Wilms tumor) and breast and pancreatic cancers, respectively

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Izquierdo-Condoy, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Oncogenic signaling pathways, which control cancer cell activity, escape of apoptosis, and tumor cell proliferation, are identified as targets for peptides targeting abnormal cellular signaling pathways