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In SURMOUNT-1, the most common treatment-emergent adverse events were gastrointestinal: nausea (24.6-33.3% across doses vs 9.5% placebo), diarrhea (18.7-21.2%), vomiting (5.7-12.2%), and constipation (5.8-11.5%)

On the other hand, compounded semaglutide may contain additional ingredients such as vitamin B-12, vitamin B-6, L-carnitine, and others

Regarding GI issues, the authors of the study linked them to a ketogenic flu, characterized by diarrhea and cramps [189]

[4] The work observed that models exposed to MT-1 exhibited a reported 75% increase in pigmentation and roughly 47% less burn

Yes, these two medications can generally be used together under specialist supervision, though careful monitoring is essential