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For a class of drugs already transforming millions of lives, this approach could further enhance both efficacy and tolerability, underscoring that responses to GLP-1 therapies are shaped not only by pharmacology but also by the subtle variations of the human genome

Expression of Glucagon-like Peptide-1 Receptor in Papillary Thyroid Carcinoma and Its Clinicopathologic Significance

That distinction matters clinically

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Furthermore, a splice variant of OCTN2 that results in an insertion in the ECD leads to retention of the transporter in the endoplasmic reticulum 33