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Thus, the concentration and bioavailability of these drugs in target tissues are increased

Further investigations into drug discovery, alongside preclinical and clinical studies focusing on key components of ARBE, are recommended due to their predicted interactions with multiple targets, particularly the central hubs

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Among the kinase-mediated signalling that influences Nrf2 activity, it is worth mentioning the phosphoinositide-3-kinase (PI3K) pathway, the AMP kinase-dependent energy deficient metabolic response and the PERK-induced unfolded protein response (UPR)