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For example, patients with certain GLP1R variants may experience heightened appetite suppression from GLP-1 medications, making even modest fasting windows feel manageable

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This effect is attributed to semaglutide GLP-1s mechanism of action, which mimics a naturally occurring hormone that regulates appetite and calorie intake, leading to a reduced hunger sensation and caloric intake

Medications like antihistamines and nasal sprays may temporarily relieve symptoms, but they don't address the root cause

The results showed that compared with the model group, the medium (150 mcg/kg) and high (300 mcg/kg) dose groups of semaglutide significantly increased GLP-1R expression, BMD and serum levels of bone formation markers (BALP, OCN)