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Superoxide dismutase helps regulate the production of antioxidant enzymes, including catalase (CAT) and glutathione peroxidase (GPx), which are required to neutralize reactive oxygen species (ROS)

Three dual agonists (peptide 15, MEDI0382 and SAR425899) and one triple agonist (peptide 20) were evaluated at GLP-1R and GCGR, relative to the native peptidic ligands (GLP-1 and glucagon)

SASP (Senescence-Associated Secretory Phenotype) signaling begins declining as the source cells are eliminated Weeks 2-6: Tissue microenvironments improve as SASP-driven inflammation decreases

NASH/MASH Studies: Phase 2 trials have evaluated the compound in non-alcoholic fatty liver disease, with reductions in liver fat observed

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